WebJan 24, 2011 · The ATP-dependent chromatin-remodeling enzyme brahma-related gene 1 (BRG1) regulates transcription of specific target genes during embryonic and postnatal development. Deletion of Brg1 from … The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed b…
SMARCA4/BRG1–Deficient Non–Small Cell Lung Carcinomas: A …
WebJan 24, 2011 · Our data demonstrate that BRG1 impacts the canonical Wnt pathway at two different levels in vascular endothelium: through transcriptional regulation of both Wnt receptor genes and Wnt target … WebMay 13, 2024 · BRG1 suppresses R-loops and associated genome instability A total of 1,722 mutations have been identified in BRG1 that accumulate preferentially at the … jjay federal work study
The chromatin-remodeling enzyme BRG1 modulates …
WebMar 13, 2024 · Further experiments showed that OCT4 needs a protein called BRG1 in order to act as a pioneer transcription factor. BRG1 is an enzyme that is able to move and remove (remodel) nucleosomes attached to DNA, suggesting that normal transcription factor binding requires this activity. WebDec 8, 2016 · To identify Brg1-expressing cells, we carried out co-immunostaining for Brg1 and myocardium-specific myosin heavy chain (MF20), endocardial/endothelial reporter Tg ( flk1 :nucEGFP),... WebMay 15, 2008 · BRG1 rearrangement was examined by semi-quantitative PCR and by quantitative PCR. C, PCR detection of BRG1 rearrangement in various tissues. The presence of a band (s) in lung tissue is confirmatory that BRG1 is being rearranged. D, quantitative PCR results for BRG1 rearrangement from each tissue. BRG1 … jjay directory