WebApr 3, 2024 · The importin α family also has an important role in the regulation of myogenesis, wherein myoblasts undergo differentiation, proliferation, and cell division. Myoblast proliferation has been found to be regulated both positively and negatively by KPNA1 (importin α5) and KPNA2 (importin α1), which suggests the import of particular … WebSep 14, 2012 · Organisms are continuously exposed to DNA damaging agents, consequently, cells have developed an intricate system known as the DNA damage response (DDR) in order to detect and repair DNA lesions. This response has to be rapid and accurate in order to keep genome integrity. It has been observed that the condensation state of chromatin …
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WebOct 2, 2024 · A loss-of-function genetic screen uncovered the nucleoporin POM121 as a key regulator of prostate cancer aggressiveness. POM121 was upregulated in advanced lethal prostate tumors, and its depletion disrupted nuclear import and suppressed prostate cancer cell growth in soft agar without altering nuclear pore complex integrity. WebThese complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. ... (Olympus FV10i) of methanol-fixed HeLa, using POM121(GTX102128) antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with GTX11305 (Red) at 1:500. GTX102128 IHC-P Image ... cts elcot
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WebDescription: Homo sapiens POM121 transmembrane nucleoporin C (POM121C), transcript variant 1, mRNA. (from RefSeq NM_001099415) Gencode Transcript: … WebAbstract. Background: The aim of this study was to confirm the role of nuclear pore membrane protein 121(POM121) in oral squamous cell carcinoma and to explore the underlying mechanism. Methods: POM121mRNA and protein expressions were evaluated in OSCC tissues and normal oral tissues by quantitative real-time polymerase chain reaction … WebJun 11, 2024 · Furthermore, we found that karyopherin-β1 (KPNB1), which belongs to the importin-β family, interacts with Pom121 and is involved in Pom121-mediated PIC nuclear import. ear training music with keyboard